Modeling Human Disease in a Dish

Our lab utilizes patient-specific iPSC derivatives to recapitulate the disease progression in a dish. Using this system, we were able to determine disease-specific cellular phenotypes, and provide novel mechanistic insights that could lead to new therapeutic strategies for heart and lung regeneration. Recent efforts have been focusing on developing more complex iPSC based systems using three-dimensional organoids, tissue-engineering, and microfluidic organ-on-a-chip platforms to better characterize the mechanic features of the cardiac tissue and cell-cell communication.

References:

Gu et. al., European Heart Journal, 2015

Sa, Gu et. al., American Journal of Respiratory and Critical Care Medicine, 2017;