Selected Publication

*denotes corresponding author.

  1. Gu M*, Zorn AM*. Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids. Cell Stem Cell. 2021 Dec 2. PMID: 34861142

  2. Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Wei Y, Moonen JR, Zhang H, Ma N, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson JT, Nie S, Wu SM, Gu M*. Intrinsic Endocardial Defects in Hypoplastic Left Heart Syndrome. Cell Stem Cell. 2020 Aug 10;S1934-5909(20)30353-2. PMID: 32810435

  3. Liu Z, Liu Y, Yu Z, Tan C, Pek N, ODonnell A, Wu A, Glass I, Winlaw D, Guo M, Spence JR, Chen YW, Yutzey KE, Miao Y, Gu M*. APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling. Nature Cardiovascular Research. 2024 June.

  4. Yu Z, Zhou X, Liu Z, Pastrana-Gomez V, Liu Y, Guo M,Tian L, Nelson TJ, Snyder MP, Wang N, Mital S, Chitayat D, Wu JC, Rabinovitch M, Wu SM, Synder MP, Miao Y, Gu M*. KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome. Circulation Research. 2022 Jul 22;131(3):280-282. PMID: 35762338

  5. Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP, Rabinovitch M. Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers. Cell Stem Cell, 2017 Apr 6;20(4):490-504.e5. PMID: 28017794

  6. Gu M, Donato M, Guo M, Wary N, Miao Y, Mao S, Saito T, Otsuki S, Wang L, Harper R, Sa S, Khatri P, Rabinovitch M. iPSC-endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin AG1296 for pulmonary arterial hypertension. Science Translational Medicine. 2021 May 5. PMID: 33952674

  7. Gillich A, Zhang F, Farmer CG, Travaglini KJ, Tan SY, Gu M, Zhou B, Feinstein JA, Krasnow MA, Metzger RJ. Capillary cell-type specialization in the alveolus. Nature. 2020 Oct 14. doi: 10.1038/s41586-020-2822-7. PMID: 33057169

  8. Ameen M, Sundaram L, Banerjee A, Shen M, Kundu S, Nair S, Shcherbina A, Gu M, Wilson KD, Varadarajan A, Vadgama N, Balsubramani A, Wu JC, Engreitz J, Farh K, Karakikes I, Wang K, Quertermous T, Greenleaf W, Kundaje A. Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease. Cell. 2022 Dec 22;185(26):4937-4953.e23. PMID: 36563664

2024

  1. Liu Z, Liu Y, Yu Z, Tan C, Pek N, ODonnell A, Wu A, Glass I, Winlaw D, Guo M, Spence JR, Chen YW, Yutzey KE, Miao Y, Gu M*. APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling. Nature Cardiovascular Research. 2024 June.

  2. Pek N, Gu M*. Utility of Lung Organoids to Accelerate Our Understanding of Human Pulmonary Development and Diseases. Lung Biology and Pathophysiology. Jan 2024.

  3. Miao Y, Tan C, Pek N, Yu Z, Iwasawa K, Kechele DO, Sundaram N, Pastrana-Gomez V, Kishimoto K, Yang M, Jiang C, Tchieu J, Whitsett JA, McCracken KW, Rottier RJ, Kotton DN, Helmrath MA, Wells JM, Takebe T, Zorn AM, Chen Y, Guo M, Gu M*. Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids. bioRxiv. https://doi.org/10.1101/2024.02.06.577460

  4. Naito C, Kosar K, Kishimoto E, Pena L, Huang Y, Hao K, Bernieh A, Kasten J, Villa C, Kishnani P, Deeksha B, Gu M, Asai A. Induced pluripotent stem cell (iPSC) modeling validates reduced GBE1 enzyme activity due to a novel variant, p.Ile694Asn, found in a patient with suspected glycogen storage disease IV. Molecular Genetics and Metabolism Reports. March 2024.

  5. Dao L, You Z, Lu L, Xu T, Sarkar AK, Zhu H, Liu M, Calandrelli R, Yoshida G, Lin P, Miao Y, Mierke S, Kalva S, Zhu H, Gu M, Vadivelu S, Zhong S, Huang LF, Guo Z. Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids. Cell Stem Cell. May 2024.

  6. Tian C, Cai H, Ao Z, Gu L, Li X, Niu V, Bondesson M, Gu M, Mackie K, Guo F. Engineering human midbrain organoid microphysiological systems to model prenatal PFOS exposure. Science of The Total Environment. July 2024.

  7. Gu L, Cai H, Chen L, Gu M, Tchieu J, Guo F. Functional Neural Networks in Human Brain Organoids. 02 Sep 2024.

2023

  1. Liu CZ, Prasad A, Jadhav B, Liu Y, Gu M, Sharp AJ, Gelb BD. Feeder-Free Generation and Characterization of Endocardial and Cardiac Valve Cells from Human Pluripotent Stem Cells. iScience. In Press. 2023 Nov.

  2. Cai H, Ao Z, Tian C, Wu Z, Liu H, Tchieu J, Gu M, Mackie K, Guo F. Brain Organoid Reservoir Computing for Artificial Intelligence. Nature Electronics. Dec 2023. PMID: 36909615

  3. Wang L, Moonen JR, Can A, Isobe S, Li CG, Tojais NF, Taylor S, Marciano DP, Chen PI, Gu M, Li D, Harper RL, EI-Bizri N, Kim YM, Stankunas K, Rabinovitch M. Dysregulated Smooth Muscle Cell BMPR2 – ARRB2 Axis Causes Pulmonary Hypertension. Circulation Research. 2023 Mar 3;132(5):545-564. PMID: 36744494

  4. Wu Z, Ao Z, Cai H, Li X, Chen B, Tu H, Wang Y, Lu RO, Gu M, Cheng L, Lu X, Guo F. Acoustofluidic assembly of primary tumor-derived organotypic cell clusters for rapid evaluation of cancer immunotherapy, Journal of Nanobiotechnology, 2023 Feb 4;21(1):40. PMID: 36739414

  5. Cai H, Ao Z, Tian C, Wu Z, Kaurich C, Chen Z, Gu M, Hohmann AG, Machie K, Guo F. Engineering human spinal microphysiological systems to model opioid-induced tolerance. Bioactive Materials. April 2023, Pages 482-490

  6. Liu Z, Lami B, Ikonomou L, Gu M. Unlocking the Potential of Induced Pluripotent Stem Cells for Neonatal Disease Modeling and Drug Development. Seminars in Perinatology. March 2023.

  7. Culley MK, Rao RJ, Mehta M, Zhao J, El Khoury W, Harvey LD, Perk D, Tai YY, Tang Y, Shiva S, Rabinovitch M, Gu M, Bertero T, Chan SY. Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function. Vascular Pharmacology. May 2023. PMID: 37164245

  8. Liu Z, Liu Y, Yu Z, Pek N, ODonnell A, Glass I, Winlaw D, Guo M, Chen YW, Wu JC, Yutzey KE, Miao Y, Gu M*. APOE-NOTCH Axis Governs Elastogenesis During Human Cardiac Valve Remodeling. bioRxiv. https://doi.org/10.1101/2023.04.26.538443

  9. Guo M, Wikenheiser-Brokamp KA, Kitzmiller JA, Jiang C, Wang G, Wang A, Preissl S, Hou X, Buchanan J, Karolak JA, Miao Y, Frank DB, Zacharis WJ, Sun X, Gu M, Stankiewicz P, Kalinichenko VV, Wambach JA, Whitsett JA. Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. July 18, 2023. PMID: 37463497

2022

  1. Ao Z, Cai H, Wu Z, Hu L, Li X, Kaurich C, Gu M, Cheng L, Lu X, Guo F. Evaluation of cancer immunotherapy using mini-tumor chips. Theranostics. 12(8):3628-3636 01 Jan 2022

  2. Chang X, Gu M, Tchieu J. Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders. Cells. 2022 Jan 28. PMID: 35159270

  3. Yu Z, Pek N, Gu M*. Delving into the Molecular World of Single Ventricle Congenital Heart Disease. Current Cardiology Reports. 2022 Jan. PMID: 35218503

  4. Toth A, Steinmeyer S, Kannan P, Gray J, Jackson CM, Mukherjee S, Demmert M, Sheak JR, Benson D, Kitzmiller J, Wayman JA, Presicce P, Cates C, Rubin R, Chetal K, Du Y, Miao Y, Gu M, Guo M, Kalinichenko VV, Kallapur SG, Miraldi ER, Xu Y, Swarr D, Lewkowich I, Salomonis N, Miller L, Sucre JS, Whitsett JA, Chougnet CA, Jobe AH, Deshmukh H, Zacharias WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022 Feb. PMID: 35353543

  5. Gillich A, Brownfield DG, Travaglini KJ, Zhang F, Farmer CG, St Julien KR, Tan SY, Gu M, Zhou B, Feinstein JA, Metzger RJ.; Krasnow MA. Dissecting alveolar patterning and maintenance at single-cell resolution. FASEB J 36 Suppl 1:May 2022

  6. Ao Z, Wu Z, Cai H, Hu L, Li X, Kaurich C, Chang J, Gu M, Liang C, Lu X, Guo F. Rapid Profiling of Tumor-Immune Interaction Using Acoustically Assembled Patient-Derived Cell Clusters. Advanced Science (Weinh) e2201478 25 May 2022

  7. Taylor S, Isobe S, Cao A, Contrepois K, Benayoun BA, Jiang L, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Moonen J-R, Marciano DP, Gu M, Miyagawa K, Hayes B, Sierra RG, Kupitz CJ, Del Rosario PA, Hsi A, Thompson AAR, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M. Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 13 Jun 2022. PMID: 35696338

  8. Yu Z, Zhou X, Liu Z, Pastrana-Gomez V, Liu Y, Guo M,Tian L, Nelson TJ, Snyder MP, Wang N, Mital S, Chitayat D, Wu JC, Rabinovitch M, Wu SM, Synder MP, Miao Y, Gu M*. KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome. Circulation Research. 2022 Jul 22;131(3):280-282. PMID: 35762338

  9. Ao Z, Song S, Tian C, Cai H, Li X, Miao Y, Wu Z, Krzesniak J, Ning B, Gu M, Lee LP, Guo F. Understanding Immune-Driven Brain Aging by Human Brain Organoid Microphysiological Analysis Platform. Advanced Science. 2022 Jul 31;e2200475.  PMID: 35908805

  10. Liu B, Yi D, Yu Z, Pan J, Ramirez K, Li S, Wang T, Glembotski C, Fallon M, Oh S, Gu M, Kalucka J, Dai Z. TMEM100, a Lung-Specific Endothelium Gene. Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). doi: 10.1161/ATVBAHA.122.317683. PMID: 36252125

  11.  Yu Z, Liu Z, Ravichandran V, Lami B, Gu M. Endocardium in Hypoplastic Left Heart Syndrome: Implicates from In Vitro Study. Journal of Cardiovascular Development and Disease. 2022 Dec 8.

  12. Pradhan A, Che L, Ustiyan V, Reza AA, Pek NM, Zhang Y, Alber AB, Kalin TR, Wambach JA, Gu M, Kotton DN, Ziady AG, Kalin TV, Kalinichenko VV. Novel FOXF-1-stablizing compound TanFe stimulates lung angiogenesis in alveolar capillary dysplasia. American Journal of Respiratory and Critical Care Medicine, 2022 Dec 8. doi: 10.1164/rccm. PMID: 36480964

  13. Ameen M, Sundaram L, Banerjee A, Shen M, Kundu S, Nair S, Shcherbina A, Gu M, Wilson KD, Varadarajan A, Vadgama N, Balsubramani A, Wu JC, Engreitz J, Farh K, Karakikes I, Wang K, Quertermous T, Greenleaf W, Kundaje A. Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease. Cell. 2022 Dec 22;185(26):4937-4953.e23. PMID: 36563664

2021

  1. Niu C, Wang S, Guo J, Wei X, Jia M, Chen Z, Gong W, Qin Y, Wang X, Zhi X, Lu M, Chen S, Gu M, Zhang J, Han J, Lan F, Meng D. BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer-promoter activity and maintains pluripotency. Nucleic Acids Research. 2021 Jan 27. PMID: 33503260

  2. Gu M, Donato M, Guo M, Wary N, Miao Y, Mao S, Saito T, Otsuki S, Wang L, Harper R, Sa S, Khatri P, Rabinovitch M. iPSC-endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin AG1296 for pulmonary arterial hypertension. Science Translational Medicine. 2021 May 5. PMID: 33952674

  3. Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock C-SC, Handen A, Speyer G, Kim S, Lai Y-C, Satoh T, Watson A, Al Aaraj Y, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar A, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. Journal of Clinical Investigation. 2021 Apr 27. PMID:33905372

  4. Bejjani AT, Wary N, Gu M*. Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration. Expert Opinion on Therapeutic Targets. 2021 Sep 07. PMID:34488532

  5. Yu Z, Zhou X, Pastrana-Gomez V, Tian L, Nelson TJ, Snyder MP, Wang N, Mital S, Chitayat D, Wu JC, Rabinovitch M, Wu SM, Miao Y, Gu M*. Abnormal Differentiation and Proliferation of Coronary Arterial Endothelium in Hypoplastic Left Heart Syndrome. bioRxiv 2021.08.30.457716;

  6. Toth A, Steinmeyer S, Kannan P, Gray J, Jackson CM, Mukherjee S, Demmert M, Sheak JR, Benson D, Kitzmiller J, Wayman JA, Presicce P, Cates C, Rubin R, Chetal K, Du Y, Miao Y, Gu M, Guo M, Kalinichenko VV, Kallapur SG, Miraldi ER, Xu Y, Swarr D, Lewkowich I, Salomonis N, Miller L, Sucre JS, Whitsett JA, Chougnet CA, Jobe AH, Deshmukh H, Zacharias WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. bioRxiv 2021.06.24.449766;

  7. Taylor S, Contrepois K, Benayoun BA, Jiang L, Isobe S, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Cao A, Moonen JR, Marciano DP, Gu M, Miyagawa K, Del Rosario AP, Hsi A, Thompson RA, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M. Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension. bioRxiv 2021.01.08.426001;

  8. Wang M, Gu M, Liu L, Liu Y, Tian L. Single-cell RNA sequencing in cardiac tissue: Applications and limitations. Vascular Health and Risk Management. 2021 Oct 2.

  9. Gu M*, Zorn AM*. Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids. Cell Stem Cell. 2021 Dec 2. PMID: 34861142

  10. Pek N, Gu M*. Growing With the Flow: Insights Into How Flow Mediates Endocardial Fibroelastosis. JACC: Basic to Translational Science. 2021 Dec 27.

2020

  1. Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Wei Y, Moonen JR, Zhang H, Ma N, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson JT, Nie S, Wu SM, Gu M*. Intrinsic Endocardial Defects in Hypoplastic Left Heart Syndrome. Cell Stem Cell. 2020 Aug 10;S1934-5909(20)30353-2. PMID: 32810435

  2. Mikryukov AA, Mazine A, Wei B, Yang D, Miao Y, Gu M, Keller G. BMP10 signaling promotes the development of endocardial cells from human pluripotent stem cell-derived cardiovascular progenitors. Cell Stem Cell. 2020 Nov. PMID: 33142114

  3. Gillich A, Zhang F, Farmer CG, Travaglini KJ, Tan SY, Gu M, Zhou B, Feinstein JA, Krasnow MA, Metzger RJ. Capillary cell-type specialization in the alveolus. Nature. 2020 Oct 14. doi: 10.1038/s41586-020-2822-7. PMID: 33057169

  4. Klein A, Bayrau B, Miao Y, Gu M*. Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart. Journal of visualized experiments: JoVE. 2020 Apr 15;(158). doi: 10.3791/61126. PMID: 32364545

  5. Wilson K, Ameen M, Guo H, Abilez OJ, Tian L, Mumbach MR, Diecke S, Qin X, Liu Y, Yang H, Ma N, Gaddam S, Cunnigham N, Gu M, Neofytou E, Prado M, Hildebrandt TB, Karakikes I, Chang H, Wu JC. Endogenous retrovirus-derived BANCR promotes cardiomyocyte migration in humans and non-human primates. Developmental Cell. 2020 Jul 28;S1534-5807(20)30580-3. PMID: 32763147

  6. Palomares A, Gu M, Grubert F, Berest I, Sa S, Kasowski M, Arnold C, Shuai M, Srivas R, Miao S, Li D, Synder M, Rabinovitch M, Zaugg J. Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension. Nature Communication. 2020 Apr 3;11(1):1673. doi: 10.1038/s41467-020-15463-x. PMID: 32245974

  7. Paige S, Galdos FX, Lee Ssoah, Chin ET, Ranjbarvaziri S, Feyen D, Darsha AK, Xu S, Ryan J, Beck A, Qureshi Y, Miao Y, Gu M, Bernstein D, Nelson T, Mercola M, Rabinovitch M, Ashley E, Parikh V, Wu SM. Patient-Specific Induced Pluripotent Stem Cells Implicate Intrinsic Impaired Contractility in Hypoplastic Left Heart Syndrome. Circulation. 2020 Oct 20;142(16):1605-1608. PMID: 33074758

  8. Zhang J, He Y, Yan X, Chen S, He M, Lei Y, Zhang J, Gongol B, Gu M, Miao Y, Bai L, Cui X, Wang X, Zhang Y, Fan F, Li Z, Shen Y, Chou C, Huang H, Malhotra A, Rabinovitch M, Jing Z, Shyy J. MicroRNA-483 Amelioration of Experimental Pulmonary Hypertension. EMBO Molecular Medicine. 2020 May 8;12(5):e11303. doi: 10.15252/emmm.201911303. PMID: 32324970

Before 2020

  1. Gu M*. Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Cells. Curr Protoc Hum Genet. 2018 Jul 6:e64. doi: 10.1002/cphg.64. PMID: 29979824

  2. Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP, Rabinovitch M. Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers. Cell Stem Cell, 2017 Apr 6;20(4):490-504.e5. PMID: 28017794

  3. Sa S, Gu M* (co-first author), Chappell J, Shao NY, Ameen M, Elliott KA, Li D, Grubert F, Li CG, Taylor S, Cao A, Ma Y, Fong R, Nguyen L, Wu JC, Snyder MP, Rabinovitch M. Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity. American Journal of Respiratory and Critical Care Medicine, 2017 Apr 1;195(7):930-941. PMID: 27779452

  4. Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC. Pravastatin Reverses Obesity-induced Dysfunction of Induced Pluripotent Stem Cell-Derived Endothelial Cells via a Nitric Oxide- Dependent Mechanism. European Heart Journal. 2015; 36 (13): 806-816. PMID: 25368203

  5. Gu M, Nguyen PK, Lee AS, Xu D, Hu S, Plews J, Han L, Huber BC, Lee WH, Gong Y, de Almeida PE, Lyons J, Ikeno F, Pacharinsak C, Connolly AJ, Gambhir SS, Robbins RC, Longaker MT, Wu JC. Microfluidic Single Cell Analysis Show Porcine Induced Pluripotent Stem Cell-Derived Endothelial Cells Improve Myocardial Function by Paracrine Activation. Circulation Research. 2012; 111 (7): 882-893. PMID: 22821929

    -Cover Story, AHA best manuscript award

  6. Gu M, Fu Y, Sun XL, Ding YZ, Li CH, Pang W, Pan S, Zhu Y. Proteomic analysis of endothelial lipid rafts reveals a novel role of statins in antioxidation. Journal of Proteome Research. 2012; 11 (4): 2365-2373. PMID: 22428589

  7. Zhang H, Tian L, Shen M, Wu H, Gu M, Tu C, Paik D, Wu JC. Generation of Quiescent Cardiac Fibroblasts from Human Induced Pluripotent Stem Cells for In Vitro Modeling of Cardiac Fibrosis. Circulation Research. 2019 Aug 16;125(5):552-566. PMID: 31288631

  8. Saito T, Miyagawa K, Chen SY, Tamosiuniene R, Wang L, Sharpe O, Samayoa E, Harada D, Moonen JR, Cao A, Chen PI, Hennigs J, Gu M, Li GC, Leib R, Li D, Adams C, A. del Rosario P, Bill M, Haddad F, Montoya J, Robinson W, Fantl W, Nolan G, Zamanian R, Nicolls M, Chiu C, Ariza M, Rabinovitch M. Upregulation of HERV-K is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension. Circulation. 2017 Nov 14;136(20):1920-1935. PMID: 28935667

  9. Churko J, Lee J, Ameen M, Gu M, Venkatasubramanian M, Diecke S, Sallam K, Im H, Wang G, Gold JD, Salomonis N, Synder M, Wu JC. Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods. Nature Biomedical Engineering. 2017 Oct;1(10):826-837. PMID: 30263871

  10. Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. Activation of Integrin α5 Mediated by Flow Requires Its Translocation to Membrane Lipid Rafts in Vascular Endothelial Cells. doi: 10.1073/pnas.1524523113. Proc Natl Acad Sci. 2016 Jan 19;113(3):769-74. PMID: 26733684

  11. Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Termglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC. Patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes elucidate single cell phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096. PMID: 27810048

  12. Hopper RK, Moonen JA, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L, Rabinovitch M. In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and its Target Slug. Circulation. 2016 Apr 4. pii: CIRCULATIONAHA.115.020617. PMID: 2704513

  13. Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ß-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015; 17 (1): 89-100. PMID: 26095046

  14. Rhodes CJ, Im H, Cao A, Hennigs JK, Wang L, Sa S, Chen PI, Nickel NP, Miyagawa K, Hopper RK, Tojais NF, Li CG, Gu M, Spiekerkoetter E, Xian Z, Chen R, Zhao M, Kaschwich M, Del Rosario PA, Bernstein D, Zamanian RT, Wu JC, Snyder MP, Rabinovitch M. RNAseq Reveals a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2015 Aug 1;192(3):356-66. PMID: 26030479

  15. Nickel NP, Spiekerkoetter E, Gu M, Li CG, Li H, Kaschwich M, Diebold I, Hennigs JK, Kim K, Miyagawa K, Wang L, Cao A, Sa S, Jiang X, Stockstill RW, Nicolls MR, Zamanian RT, Bland RD, Rabinovitch M. Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling. American Journal of Respiratory and Critical Care Medicine. 2015; 191 (11): 1273-1286. PMID: 25853696

  16. Wang Y, Liang P, Lan F, Wu H, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC. Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing. Journal of the American College of Cardiology. 2014; 64 (5): 451-459. PMID: 25082577

  17. Plews J, Gu M, Longaker MT, Wu JC. Large animal induced pluripotent stem cells as pre-clinical models for studying human disease. Journal of Cellular and Molecular Medicine. 2012; 16 (6): 1196-1202. PMID: 22212700

  18. Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy JY, Zhu Y. A Novel Mechanism of gamma/delta T-Lymphocyte and Endothelial Activation by Shear Stress: The Role of Ecto-ATP Synthase beta Chain. Circulation Research. 2011; 108 (4): 410-417. PMID: 21193741